Direct evidence of the temperature dependence of Gd-BOPTA transport in the intact rat liver.
نویسندگان
چکیده
The aim was to study the influence of temperature on the transport of the hepatobiliary contrast agent Gadobenate dimeglumine (Gd-BOPTA). Rat livers were isolated and perfused with Gd-BOPTA at 12, 25, 30, 36 and 38 degrees C. After the perfusion period, biopsies were collected and the MR signal intensity was measured. Uptake and biliary excretion were quantified with radiolabeled Gd-BOPTA. MR signal intensity decreased with temperature of perfusion. This phenomenon was appropriately quantified with 153Gd and 153Sm labeling, in contrast to 67Ga.
منابع مشابه
Quantification of Gd-BOPTA uptake and biliary excretion from dynamic magnetic resonance imaging in rat livers: model validation with 153Gd-BOPTA.
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عنوان ژورنال:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
دوره 62 6 شماره
صفحات -
تاریخ انتشار 2005